5LXM: Crystal structure of Aurora-A bound to a hydrocarbon-stapled proteomimetic of TPX2

PDB ID: 5LXMDownload
MMDB ID: 144588
PDB Deposition Date: 2016/9/22
Updated in MMDB: 2016/12
Experimental Method:
x-ray diffraction
Resolution: 2.08  Å
Source Organism:
Similar Structures:
Biological Unit for 5LXM: dimeric; determined by author and by software (PISA)
Molecular Components in 5LXM
Label Count Molecule
Proteins (2 molecules)
1
Aurora Kinase a
(Gene symbol: AURKA)
Molecule annotation
1
Targeting Protein for Xklp2
(Gene symbol: TPX2)
Molecule annotation
Chemicals and Non-standard biopolymers (11 molecules)
1
1
ADENOSINE-5'-DIPHOSPHATEADENOSINE-5'-DIPHOSPHATE
2
1
TETRAETHYLENE GLYCOLTETRAETHYLENE GLYCOL
3
1
SULFATE IONSULFATE ION
4
2
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
5
1
2-(N-MORPHOLINO)-ETHANESULFONIC ACID2-(N-MORPHOLINO)-ETHANESULFONIC ACID
6
1
1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE
7
1
CHLORIDE IONCHLORIDE ION
8
2
MAGNESIUM IONMAGNESIUM ION
9
1
Molecule information is not available.
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303