5LWN: Crystal Structure Of Jak3 In Complex With Compound 5 (fm409)

PDB ID: 5LWNDownload
MMDB ID: 144424
PDB Deposition Date: 2016/9/18
Updated in MMDB: 2016/12
Experimental Method:
x-ray diffraction
Resolution: 1.6  Å
Source Organism:
Similar Structures:
Biological Unit for 5LWN: monomeric; determined by software (PISA)
Molecular Components in 5LWN
Label Count Molecule
Protein (1 molecule)
1
Tyrosine-protein Kinase Jak3
(Gene symbol: JAK3)
Molecule annotation
Chemicals and Non-standard biopolymers (9 molecules)
1
1
1-Phenylurea1-Phenylurea
2
6
1,2-Ethanediol1,2-Ethanediol
3
1
(~{z})-2-Cyano-~{n},~{n}-Dimethyl-3-[5-[3-[(1~{s},2~{r})-2-Methylcyclohexyl]-3,5,8,10-Tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1,4,6,8,11-Pentaen-4-Yl]furan-2-Yl]prop-2-Enamide(~{z})-2-Cyano-~{n},~{n}-Dimethyl-3-[5-[3-[(1~{s},2~{r})-2-Methylcyclohexyl]-3,5,8,10-Tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1,4,6,8,11-Pentaen-4-Yl]furan-2-Yl]prop-2-Enamide
4
1
(2~{s})-2-Cyano-~{n},~{n}-Dimethyl-3-[5-[3-[(1~{s},2~{r})-2-Methylcyclohexyl]-3,5,8,10-Tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1,4,6,8,11-Pentaen-4-Yl]furan-2-Yl]propanamide(2~{s})-2-Cyano-~{n},~{n}-Dimethyl-3-[5-[3-[(1~{s},2~{r})-2-Methylcyclohexyl]-3,5,8,10-Tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1,4,6,8,11-Pentaen-4-Yl]furan-2-Yl]propanamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303