5LV2: Crystal structure of mouse CARM1 in complex with inhibitor LH1246

PDB ID: 5LV2Download
MMDB ID: 154568
PDB Deposition Date: 2016/9/12
Updated in MMDB: 2025/12
Experimental Method:
x-ray diffraction
Resolution: 2.29  Å
Source Organism:
Similar Structures:
Biological Unit for 5LV2: tetrameric; determined by author
Molecular Components in 5LV2
Label Count Molecule
Proteins (4 molecules)
4
Histone-arginine Methyltransferase Carm1
(Gene symbol: Carm1)
Molecule annotation
Chemicals and Non-standard biopolymers (15 molecules)
1
2
5'-S-[(3S)-3-azaniumyl-3-carboxypropyl]-5'-thioadenosine5'-S-[(3S)-3-azaniumyl-3-carboxypropyl]-5'-thioadenosine
2
5
1,2-ETHANEDIOL1,2-ETHANEDIOL
3
2
5-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylamino]methyl]-4-azanyl-1-(methoxymethyl)pyrimidin-2-one5-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylamino]methyl]-4-azanyl-1-(methoxymethyl)pyrimidin-2-one
4
2
TETRAETHYLENE GLYCOLTETRAETHYLENE GLYCOL
5
1
1-METHOXY-2-(2-METHOXYETHOXY)ETHANE1-METHOXY-2-(2-METHOXYETHOXY)ETHANE
6
1
1,2-DIMETHOXYETHANE1,2-DIMETHOXYETHANE
7
1
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
8
1
SODIUM IONSODIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303