5LS6: Structure of Human Polycomb Repressive Complex 2 (PRC2) with inhibitor

PDB ID: 5LS6Download
MMDB ID: 147526
PDB Deposition Date: 2016/8/22
Updated in MMDB: 2019/07
Experimental Method:
x-ray diffraction
Resolution: 3.47  Å
Source Organism:
Similar Structures:
Biological Unit for 5LS6: tetrameric; determined by author
Molecular Components in 5LS6
Label Count Molecule
Proteins (4 molecules)
1
Histone-lysine N-methyltransferase Ezh2,histone-lysine N-methyltransferase Ezh2,histone-lysine N-methyltransferase Ezh2
(Gene symbol: EZH2)
Molecule annotation
1
Polycomb Protein EED
(Gene symbol: EED)
Molecule annotation
1
Polycomb Protein Suz12
(Gene symbol: SUZ12)
Molecule annotation
1
Jarid2 K116me3
Molecule annotation
Chemicals and Non-standard biopolymers (9 molecules)
1
8
ZINC IONZINC ION
2
1
1-[(1~{R})-1-[1-[2,2-bis(fluoranyl)propyl]piperidin-4-yl]ethyl]-~{N}-[(4-methoxy-6-methyl-2-oxidanylidene-3~{H}-pyridin-3-yl)methyl]-2-methyl-indole-3-carboxamide1-[(1~{R})-1-[1-[2,2-bis(fluoranyl)propyl]piperidin-4-yl]ethyl]-~{N}-[(4-methoxy-6-methyl-2-oxidanylidene-3~{H}-pyridin-3-yl)methyl]-2-methyl-indole-3-carboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303