5LCK: A Clickable Covalent ERK 1/2 Inhibitor

PDB ID: 5LCKDownload
MMDB ID: 140858
PDB Deposition Date: 2016/6/22
Updated in MMDB: 2024/10
Experimental Method:
x-ray diffraction
Resolution: 1.89  Å
Source Organism:
Similar Structures:
Biological Unit for 5LCK: monomeric; determined by software (PISA)
Molecular Components in 5LCK
Label Count Molecule
Protein (1 molecule)
1
Mitogen-activated Protein Kinase 1
(Gene symbol: MAPK1)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
4
SULFATE IONSULFATE ION
2
1
~{N}-[2-[[2-[(5-methoxypyridin-3-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]propanamide~{N}-[2-[[2-[(5-methoxypyridin-3-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]propanamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303