5L3A: Fragment-based discovery of 6-arylindazole JAK inhibitors

PDB ID: 5L3ADownload
MMDB ID: 138649
PDB Deposition Date: 2016/4/6
Updated in MMDB: 2019/10
Experimental Method:
x-ray diffraction
Resolution: 1.98  Å
Source Organism:
Similar Structures:
Biological Unit for 5L3A: monomeric; determined by author and by software (PISA)
Molecular Components in 5L3A
Label Count Molecule
Protein (1 molecule)
1
Tyrosine-protein Kinase Jak2
(Gene symbol: JAK2)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
~{N}-(1~{H}-indazol-4-yl)methanesulfonamide~{N}-(1~{H}-indazol-4-yl)methanesulfonamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303