5L2W: The X-ray co-crystal structure of human CDK2/CyclinE and Dinaciclib

PDB ID: 5L2WDownload
MMDB ID: 236495
PDB Deposition Date: 2016/8/2
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 2.8  Å
Source Organism:
Similar Structures:
Biological Unit for 5L2W: dimeric; determined by author and by software (PISA)
Molecular Components in 5L2W
Label Count Molecule
Proteins (2 molecules)
1
Cyclin-dependent Kinase 2
(Gene symbol: CDK2)
Molecule annotation
1
G1/s-specific Cyclin-e1
(Gene symbol: CCNE1)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
3-[({3-ethyl-5-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)methyl]-1-hydroxypyridinium3-[({3-ethyl-5-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)methyl]-1-hydroxypyridinium
2
1
GLYCEROLGLYCEROL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303