5KZI: Crystal structure of human Pim-1 kinase in complex with an imidazopyridazine inhibitor

PDB ID: 5KZIDownload
MMDB ID: 144771
PDB Deposition Date: 2016/7/25
Updated in MMDB: 2016/12
Experimental Method:
x-ray diffraction
Resolution: 2.1  Å
Source Organism:
Similar Structures:
Biological Unit for 5KZI: monomeric; determined by author and by software (PISA)
Molecular Components in 5KZI
Label Count Molecule
Protein (1 molecule)
1
Serine/threonine-protein Kinase Pim-1
(Gene symbol: PIM1)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
~{N}-[4-[(3~{S})-3-azanylpiperidin-1-yl]pyridin-3-yl]-2-[2,6-bis(fluoranyl)phenyl]imidazo[1,5-b]pyridazin-7-amine~{N}-[4-[(3~{S})-3-azanylpiperidin-1-yl]pyridin-3-yl]-2-[2,6-bis(fluoranyl)phenyl]imidazo[1,5-b]pyridazin-7-amine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303