5KYK: Covalent GTP-competitive inhibitors of KRAS G12C: Guanosine bisphosphonate Analogs

PDB ID: 5KYKDownload
MMDB ID: 149688
PDB Deposition Date: 2016/7/21
Updated in MMDB: 2024/12
Experimental Method:
x-ray diffraction
Resolution: 2.702  Å
Source Organism:
Similar Structures:
Biological Unit for 5KYK: monomeric; determined by author and by software (PISA)
Molecular Components in 5KYK
Label Count Molecule
Protein (1 molecule)
1
Gtpase Kras
(Gene symbol: KRAS)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
5'-O-[(R)-[({2-[(chloroacetyl)amino]ethyl}sulfamoyl)methyl](hydroxy)phosphoryl]guanosine5'-O-[(R)-[({2-[(chloroacetyl)amino]ethyl}sulfamoyl)methyl](hydroxy)phosphoryl]guanosine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303