5KYJ: Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core

PDB ID: 5KYJDownload
MMDB ID: 143370
PDB Deposition Date: 2016/7/21
Updated in MMDB: 2017/11
Experimental Method:
x-ray diffraction
Resolution: 2.8  Å
Source Organism:
Similar Structures:
Biological Unit for 5KYJ: dimeric; determined by author and by software (PISA)
Molecular Components in 5KYJ
Label Count Molecule
Proteins (2 molecules)
1
Oxysterols Receptor Lxr-beta
(Gene symbol: NR1H2)
Molecule annotation
1
Retinoic Acid Receptor Rxr-beta
(Gene symbol: RXRB)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
(6~{R})-5-(5-fluoranyl-2-methoxy-pyrimidin-4-yl)-2-(3-methylsulfonylphenyl)-6-propan-2-yl-4,6-dihydropyrrolo[3,4-c]pyrazole(6~{R})-5-(5-fluoranyl-2-methoxy-pyrimidin-4-yl)-2-(3-methylsulfonylphenyl)-6-propan-2-yl-4,6-dihydropyrrolo[3,4-c]pyrazole
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303