5KUP: Bruton's tyrosine kinase (BTK) with pyridazinone compound 9

PDB ID: 5KUPDownload
MMDB ID: 143131
PDB Deposition Date: 2016/7/13
Updated in MMDB: 2016/11
Experimental Method:
x-ray diffraction
Resolution: 1.389  Å
Source Organism:
Similar Structures:
Biological Unit for 5KUP: monomeric; determined by author and by software (PISA)
Molecular Components in 5KUP
Label Count Molecule
Protein (1 molecule)
1
Tyrosine-protein Kinase BTK
(Gene symbol: BTK)
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
2
SULFATE IONSULFATE ION
2
2
GLYCEROLGLYCEROL
3
1
2-(2-METHOXYETHOXY)ETHANOL2-(2-METHOXYETHOXY)ETHANOL
4
1
6-~{tert}-butyl-8-fluoranyl-2-[3-(hydroxymethyl)-4-[1-methyl-6-oxidanylidene-5-(pyrimidin-4-ylamino)pyridin-3-yl]pyridin-2-yl]phthalazin-1-one6-~{tert}-butyl-8-fluoranyl-2-[3-(hydroxymethyl)-4-[1-methyl-6-oxidanylidene-5-(pyrimidin-4-ylamino)pyridin-3-yl]pyridin-2-yl]phthalazin-1-one
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303