5KU3: BRD4 bromodomain in complex with Cpd59 ((S)-1-(3-((2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)-1-(tetrahydrofuran-3-yl)-6,7-dihydro-1H-pyrazolo[4,3-c]pyridin-5(4H)-yl)ethanone)

PDB ID: 5KU3Download
MMDB ID: 144572
PDB Deposition Date: 2016/7/12
Updated in MMDB: 2016/12
Experimental Method:
x-ray diffraction
Resolution: 1.14  Å
Source Organism:
Similar Structures:
Biological Unit for 5KU3: monomeric; determined by author and by software (PISA)
Molecular Components in 5KU3
Label Count Molecule
Protein (1 molecule)
1
Bromodomain-containing Protein 4
(Gene symbol: BRD4)
Molecule annotation
Chemicals and Non-standard biopolymers (11 molecules)
1
6
1,2-ETHANEDIOL1,2-ETHANEDIOL
2
2
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
3
1
GLYCEROLGLYCEROL
4
1
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
5
1
1-[3-[[2-fluoranyl-4-(1-methylpyrazol-4-yl)phenyl]amino]-1-[(3~{S})-oxolan-3-yl]-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridin-5-yl]ethanone1-[3-[[2-fluoranyl-4-(1-methylpyrazol-4-yl)phenyl]amino]-1-[(3~{S})-oxolan-3-yl]-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridin-5-yl]ethanone
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303