5KOT: Discovery of TAK-272: A Novel, Potent and Orally Active Renin In-hibitor

PDB ID: 5KOTDownload
MMDB ID: 152383
PDB Deposition Date: 2016/7/1
Updated in MMDB: 2024/11
Experimental Method:
x-ray diffraction
Resolution: 2.1  Å
Source Organism:
Similar Structures:
Biological Unit for 5KOT: monomeric; determined by author
Molecular Components in 5KOT
Label Count Molecule
Protein (1 molecule)
1
Renin
(Gene symbol: REN)
Molecule annotation
Chemicals and Non-standard biopolymers (15 molecules)
1
1
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
1
1-(4-methoxybutyl)-~{N}-(2-methylpropyl)-~{N}-[(3~{S},5~{R})-5-morpholin-4-ylcarbonylpiperidin-3-yl]benzimidazole-2-carboxamide1-(4-methoxybutyl)-~{N}-(2-methylpropyl)-~{N}-[(3~{S},5~{R})-5-morpholin-4-ylcarbonylpiperidin-3-yl]benzimidazole-2-carboxamide
3
1
TRIETHYLENE GLYCOLTRIETHYLENE GLYCOL
4
3
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
5
9
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303