5KCV: Crystal structure of allosteric inhibitor, ARQ 092, in complex with autoinhibited form of AKT1

PDB ID: 5KCVDownload
MMDB ID: 140596
PDB Deposition Date: 2016/6/7
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 2.7  Å
Source Organism:
Similar Structures:
Biological Unit for 5KCV: monomeric; determined by author and by software (PISA)
Molecular Components in 5KCV
Label Count Molecule
Protein (1 molecule)
1
Rac-alpha Serine/threonine-protein Kinase
(Gene symbol: AKT1)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
3-[3-[4-(1-azanylcyclobutyl)phenyl]-5-phenyl-imidazo[4,5-b]pyridin-2-yl]pyridin-2-amine3-[3-[4-(1-azanylcyclobutyl)phenyl]-5-phenyl-imidazo[4,5-b]pyridin-2-yl]pyridin-2-amine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303