5KCI: Crystal Structure of HTC1

Citation:
Abstract
We show here that computer game players can build high-quality crystal structures. Introduction of a new feature into the computer game Foldit allows players to build and real-space refine structures into electron density maps. To assess the usefulness of this feature, we held a crystallographic model-building competition between trained crystallographers, undergraduate students, Foldit players and automatic model-building algorithms. After removal of disordered residues, a team of Foldit players achieved the most accurate structure. Analysing the target protein of the competition, YPL067C, uncovered a new family of histidine triad proteins apparently involved in the prevention of amyloid toxicity. From this study, we conclude that crystallographers can utilize crowdsourcing to interpret electron density information and to produce structure solutions of the highest quality.
PDB ID: 5KCIDownload
MMDB ID: 143334
PDB Deposition Date: 2016/6/6
Updated in MMDB: 2017/11
Experimental Method:
x-ray diffraction
Resolution: 1.833  Å
Source Organism:
Similar Structures:
Biological Unit for 5KCI: monomeric; determined by author and by software (PISA)
Molecular Components in 5KCI
Label Count Molecule
Protein (1 molecule)
1
Uncharacterized Protein Ypl067c(Gene symbol: YPL067C)
Molecule annotation
Chemicals (3 molecules)
1
1
2
1
3
1
* Click molecule labels to explore molecular sequence information.

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