5K4J: Crystal Structure Of Cdk2 In Complex With Compound 22

The extracellular signal-regulated kinases ERK1/2 represent an essential node within the RAS/RAF/MEK/ERK signaling cascade that is commonly activated by oncogenic mutations in BRAF or RAS or by upstream oncogenic signaling. While targeting upstream nodes with RAF and MEK inhibitors has proven effective clinically, resistance frequently develops through reactivation of the pathway. Simultaneous targeting of multiple nodes in the pathway, such as MEK and ERK, offers the prospect of enhanced efficacy as well as reduced potential for acquired resistance. Described herein is the discovery and characterization of GDC-0994 (22), an orally bioavailable small molecule inhibitor selective for ERK kinase activity.
PDB ID: 5K4JDownload
MMDB ID: 141056
PDB Deposition Date: 2016/5/20
Updated in MMDB: 2016/08
Experimental Method:
x-ray diffraction
Resolution: 1.6  Å
Source Organism:
Similar Structures:
Biological Unit for 5K4J: monomeric; determined by author and by software (PISA)
Molecular Components in 5K4J
Label Count Molecule
Protein (1 molecule)
Cyclin-dependent Kinase 2(Gene symbol: CDK2)
Molecule annotation
Chemical (1 molecule)
* Click molecule labels to explore molecular sequence information.

Citing MMDB