5JYP: Allosteric inhibition of Kidney Isoform of Glutaminase

PDB ID: 5JYPDownload
MMDB ID: 141585
PDB Deposition Date: 2016/5/15
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 2.74  Å
Source Organism:
Similar Structures:
Biological Unit for 5JYP: tetrameric; determined by author
Molecular Components in 5JYP
Label Count Molecule
Proteins (4 molecules)
4
Glutaminase Kidney Isoform, Mitochondrial
(Gene symbol: GLS)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
3
2-phenyl-~{N}-[5-[(1~{S},3~{S})-3-[5-(2-phenylethanoylamino)-1,3,4-thiadiazol-2-yl]cyclohexyl]-1,3,4-thiadiazol-2-yl]ethanamide2-phenyl-~{N}-[5-[(1~{S},3~{S})-3-[5-(2-phenylethanoylamino)-1,3,4-thiadiazol-2-yl]cyclohexyl]-1,3,4-thiadiazol-2-yl]ethanamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303