5JYO: Allosteric inhibition of Kidney Isoform of Glutaminase

PDB ID: 5JYODownload
MMDB ID: 141584
PDB Deposition Date: 2016/5/15
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 2.098  Å
Source Organism:
Similar Structures:
Biological Unit for 5JYO: heptameric; determined by author
Molecular Components in 5JYO
Label Count Molecule
Proteins (7 molecules)
7
Glutaminase Kidney Isoform, Mitochondrial
(Gene symbol: GLS)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
4
2-(pyridin-2-yl)-N-(5-{4-[6-({[3-(trifluoromethoxy)phenyl]acetyl}amino)pyridazin-3-yl]butyl}-1,3,4-thiadiazol-2-yl)acetamide2-(pyridin-2-yl)-N-(5-{4-[6-({[3-(trifluoromethoxy)phenyl]acetyl}amino)pyridazin-3-yl]butyl}-1,3,4-thiadiazol-2-yl)acetamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303