5JV2: Crystal structure of human FPPS in complex with an allosteric inhibitor MIT-01-055

PDB ID: 5JV2Download
MMDB ID: 148088
PDB Deposition Date: 2016/5/10
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 2.3  Å
Source Organism:
Similar Structures:
Biological Unit for 5JV2: dimeric; determined by author and by software (PISA)
Molecular Components in 5JV2
Label Count Molecule
Proteins (2 molecules)
2
Farnesyl Pyrophosphate Synthase
(Gene symbol: FDPS)
Molecule annotation
Chemicals and Non-standard biopolymers (10 molecules)
1
2
PHOSPHATE IONPHOSPHATE ION
2
4
CHLORIDE IONCHLORIDE ION
3
4
{[6-(4-methylphenyl)thieno[2,3-d]pyrimidin-5-yl]methyl}phosphonic acid{[6-(4-methylphenyl)thieno[2,3-d]pyrimidin-5-yl]methyl}phosphonic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303