5JHM: Crystal Structure Of Zika Virus Envelope Protein

Zika virus (ZIKV), a mosquito-borne flavivirus, is a current global public health concern. The flavivirus envelope (E) glycoprotein is responsible for virus entry and represents a major target of neutralizing antibodies for other flaviviruses. Here, we report the structures of ZIKV E protein at 2.0 A and in complex with a flavivirus broadly neutralizing murine antibody 2A10G6 at 3.0 A. ZIKV-E resembles all the known flavivirus E structures but contains a unique, positively charged patch adjacent to the fusion loop region of the juxtaposed monomer, which may influence host attachment. The ZIKV-E-2A10G6 complex structure reveals antibody recognition of a highly conserved fusion loop. 2A10G6 binds to ZIKV-E with high affinity in vitro and neutralizes currently circulating ZIKV strains in vitro and in mice. The E protein fusion loop epitope represents a potential candidate for therapeutic antibodies against ZIKV.
PDB ID: 5JHMDownload
MMDB ID: 139218
PDB Deposition Date: 2016/4/21
Updated in MMDB: 2016/05
Experimental Method:
x-ray diffraction
Resolution: 2  Å
Source Organism:
Similar Structures:
Biological Unit for 5JHM: dimeric; determined by author and by software (PISA)
Molecular Components in 5JHM
Label Count Molecule
Proteins (2 molecules)
Envelope Protein
Molecule annotation
* Click molecule labels to explore molecular sequence information.

Citing MMDB