5JCB: Microtubule depolymerizing agent podophyllotoxin derivative YJTSF1

PDB ID: 5JCBDownload
MMDB ID: 154735
PDB Deposition Date: 2016/4/14
Updated in MMDB: 2018/12
Experimental Method:
x-ray diffraction
Resolution: 2.3  Å
Source Organism:
Sus scrofa▼
Similar Structures:
Biological Unit for 5JCB: hexameric; determined by author
Molecular Components in 5JCB
Label Count Molecule
Proteins (6 molecules)
2
Tubulin Alpha-1b Chain
Molecule annotation
2
Tubulin Beta Chain
Molecule annotation
1
Stathmin
Molecule annotation
1
Tubulin-tyrosine Ligase
Molecule annotation
Chemicals and Non-standard biopolymers (30 molecules)
1
2
GUANOSINE-5'-TRIPHOSPHATEGUANOSINE-5'-TRIPHOSPHATE
2
7
MAGNESIUM IONMAGNESIUM ION
3
8
GLYCEROLGLYCEROL
4
2
IMIDAZOLEIMIDAZOLE
5
2
CALCIUM IONCALCIUM ION
6
2
GUANOSINE-5'-DIPHOSPHATEGUANOSINE-5'-DIPHOSPHATE
7
2
SODIUM IONSODIUM ION
8
1
2-(N-MORPHOLINO)-ETHANESULFONIC ACID2-(N-MORPHOLINO)-ETHANESULFONIC ACID
9
2
(5R,5aR,8aS,9R)-9-[(4H-1,2,4-triazol-3-yl)sulfanyl]-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydro-2H-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one(5R,5aR,8aS,9R)-9-[(4H-1,2,4-triazol-3-yl)sulfanyl]-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydro-2H-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
10
1
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
11
1
PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTERPHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303