5J79: The identification and pharmacological characterization of 6-(tert-butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a highly potent and selective inhibitor of RIP2 Kinase, Compound 3 complex

PDB ID: 5J79Download
MMDB ID: 139401
PDB Deposition Date: 2016/4/6
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 2.69  Å
Source Organism:
Similar Structures:
Biological Unit for 5J79: dimeric; determined by author and by software (PISA)
Molecular Components in 5J79
Label Count Molecule
Proteins (2 molecules)
2
Receptor-interacting Serine/threonine-protein Kinase 2
(Gene symbol: RIPK2)
Molecule annotation
Chemicals and Non-standard biopolymers (7 molecules)
1
2
4-methyl-3-{[6-(methylsulfonyl)quinolin-4-yl]amino}phenol4-methyl-3-{[6-(methylsulfonyl)quinolin-4-yl]amino}phenol
2
5
SULFATE IONSULFATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303