5J6D: Discovery of acyl guanidine tryptophan hydroxylase-1 inhibitors

PDB ID: 5J6DDownload
MMDB ID: 139610
PDB Deposition Date: 2016/4/4
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 1.9  Å
Source Organism:
Similar Structures:
Biological Unit for 5J6D: monomeric; determined by author
Molecular Components in 5J6D
Label Count Molecule
Protein (1 molecule)
1
Tryptophan 5-hydroxylase 1
(Gene symbol: TPH1)
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
1
FE (III) IONFE (III) ION
2
1
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
3
2
GLYCEROLGLYCEROL
4
2
4-[(N-{[2-(3-methoxyphenoxy)-6-(piperidin-1-yl)phenyl]methyl}carbamimidoyl)carbamoyl]-L-phenylalanine4-[(N-{[2-(3-methoxyphenoxy)-6-(piperidin-1-yl)phenyl]methyl}carbamimidoyl)carbamoyl]-L-phenylalanine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303