5IXS: Lactate Dehydrogenase in complex with hydroxylactam inhibitor compound 9: (6R)-3-[(2-chlorophenyl)sulfanyl]-4-hydroxy-6-(3-hydroxyphenyl)-6-(thiophen-3-yl)-5,6-dihydropyridin-2(1H)-one

PDB ID: 5IXSDownload
MMDB ID: 143076
PDB Deposition Date: 2016/3/23
Updated in MMDB: 2016/11
Experimental Method:
x-ray diffraction
Resolution: 2.05  Å
Source Organism:
Similar Structures:
Biological Unit for 5IXS: tetrameric; determined by author and by software (PISA)
Molecular Components in 5IXS
Label Count Molecule
Proteins (4 molecules)
4
L-lactate Dehydrogenase a Chain
(Gene symbol: LDHA)
Molecule annotation
Chemicals and Non-standard biopolymers (15 molecules)
1
3
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
2
3
1,4,5,6-TETRAHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE1,4,5,6-TETRAHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE
3
4
(6R)-3-[(2-chlorophenyl)sulfanyl]-4-hydroxy-6-(3-hydroxyphenyl)-6-(thiophen-3-yl)-5,6-dihydropyridin-2(1H)-one(6R)-3-[(2-chlorophenyl)sulfanyl]-4-hydroxy-6-(3-hydroxyphenyl)-6-(thiophen-3-yl)-5,6-dihydropyridin-2(1H)-one
4
4
SULFATE IONSULFATE ION
5
1
1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303