5IW0: Linked KDM5A Jmj Domain Bound to the Inhibitor N19 [2-(5-((4-chloro-2-methylbenzyl)oxy)-1H-pyrazol-1-yl)isonicotinic acid]

PDB ID: 5IW0Download
MMDB ID: 141377
PDB Deposition Date: 2016/3/21
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 1.63  Å
Source Organism:
Similar Structures:
Biological Unit for 5IW0: monomeric; determined by author
Molecular Components in 5IW0
Label Count Molecule
Protein (1 molecule)
1
Lysine-specific Demethylase 5A
(Gene symbol: KDM5A)
Molecule annotation
Chemicals and Non-standard biopolymers (7 molecules)
1
1
2-{5-[(4-chloro-2-methylphenyl)methoxy]-1H-pyrazol-1-yl}pyridine-4-carboxylic acid2-{5-[(4-chloro-2-methylphenyl)methoxy]-1H-pyrazol-1-yl}pyridine-4-carboxylic acid
2
1
2-OXOGLUTARIC ACID2-OXOGLUTARIC ACID
3
1
MANGANESE (II) IONMANGANESE (II) ION
4
2
1,2-ETHANEDIOL1,2-ETHANEDIOL
5
2
GLYCEROLGLYCEROL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303