5IV3: Crystal structure of human soluble adenylyl cyclase in complex with alpha,beta-methyleneadenosine-5'-triphosphate and the allosteric inhibitor LRE1

PDB ID: 5IV3Download
MMDB ID: 142455
PDB Deposition Date: 2016/3/18
Updated in MMDB: 2016/10
Experimental Method:
x-ray diffraction
Resolution: 1.86  Å
Source Organism:
Similar Structures:
Biological Unit for 5IV3: monomeric; determined by author and by software (PISA)
Molecular Components in 5IV3
Label Count Molecule
Protein (1 molecule)
1
Adenylate Cyclase Type 10
(Gene symbol: ADCY10)
Molecule annotation
Chemicals and Non-standard biopolymers (11 molecules)
1
2
ACETATE IONACETATE ION
2
3
GLYCEROLGLYCEROL
3
1
6-chloro-N~4~-cyclopropyl-N~4~-[(thiophen-2-yl)methyl]pyrimidine-2,4-diamine6-chloro-N~4~-cyclopropyl-N~4~-[(thiophen-2-yl)methyl]pyrimidine-2,4-diamine
4
1
DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTERDIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER
5
1
CALCIUM IONCALCIUM ION
6
1
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
7
1
1,2-ETHANEDIOL1,2-ETHANEDIOL
8
1
CHLORIDE IONCHLORIDE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303