5IU2: Discovery of imidazoquinolines as a novel class of potent, selective and in vivo efficacious COT kinase inhibitors

PDB ID: 5IU2Download
MMDB ID: 142281
PDB Deposition Date: 2016/3/17
Updated in MMDB: 2016/09
Experimental Method:
x-ray diffraction
Resolution: 2.7  Å
Source Organism:
Similar Structures:
Biological Unit for 5IU2: monomeric; determined by author
Molecular Components in 5IU2
Label Count Molecule
Protein (1 molecule)
1
Mitogen-activated Protein Kinase Kinase Kinase 8
(Gene symbol: MAP3K8)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
N-[2-(morpholin-4-yl)ethyl]-6-(8-phenyl-1H-imidazo[4,5-c][1,7]naphthyridin-1-yl)-1,3-benzothiazol-2-amineN-[2-(morpholin-4-yl)ethyl]-6-(8-phenyl-1H-imidazo[4,5-c][1,7]naphthyridin-1-yl)-1,3-benzothiazol-2-amine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303