5ISM: Human DPP4 in complex with a novel 5,5,6-tricyclic pyrrolidine inhibitor

PDB ID: 5ISMDownload
MMDB ID: 139201
PDB Deposition Date: 2016/3/15
Updated in MMDB: 2024/11
Experimental Method:
x-ray diffraction
Resolution: 2  Å
Source Organism:
Similar Structures:
Biological Unit for 5ISM: dimeric; determined by author and by software (PISA)
Molecular Components in 5ISM
Label Count Molecule
Proteins (2 molecules)
2
Dipeptidyl Peptidase 4
(Gene symbol: DPP4)
Molecule annotation
Chemicals and Non-standard biopolymers (21 molecules)
1
18
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
1
SODIUM IONSODIUM ION
3
2
(2R,3S,5R)-2-(2,5-difluorophenyl)-5-(7H-pyrrolo[3',4':3,4]pyrazolo[1,5-a]pyrimidin-8(9H)-yl)oxan-3-amine(2R,3S,5R)-2-(2,5-difluorophenyl)-5-(7H-pyrrolo[3',4':3,4]pyrazolo[1,5-a]pyrimidin-8(9H)-yl)oxan-3-amine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303