5ILF: The X-ray Structure Of The Adduct Formed In The Reaction Between Hen Egg White Lysozyme And Compound 4, A Platin(ii) Compound Containing A O, S Bidentate Ligand

Citation:
Abstract
We report on platinum(ii) complexes with different cinnamic acid derivatives as ligands with cytotoxic activity against Cisplatin resistant ovarian cancer cell line subcultures of SKOV3 and A2780. A typical mechanism of action for platinum(ii) complexes as Cisplatin itself is binding to the DNA and inducing double-strand breaks. We examined the biological behavior of these potential drugs with 9-methylguanine using NMR spectroscopic methods and their DNA damage potential including gammaH2AX-foci analyses. X-ray diffraction methods have been used to elucidate the molecular structures of the platinum(ii) complexes. Interactions with the model protein lysozyme have been evaluated by different techniques including UV-Vis absorption spectroscopy, fluorescence and X-ray crystallography.
PDB ID: 5ILFDownload
MMDB ID: 145446
PDB Deposition Date: 2016/3/4
Updated in MMDB: 2016/12
Experimental Method:
x-ray diffraction
Resolution: 1.85  Å
Source Organism:
Similar Structures:
Biological Unit for 5ILF: monomeric; determined by software (PISA)
Molecular Components in 5ILF
Label Count Molecule
Protein (1 molecule)
1
Lysozyme C(Gene symbol: LYZ)
Molecule annotation
Chemicals (8 molecules)
1
1
2
1
3
4
4
1
5
1
* Click molecule labels to explore molecular sequence information.

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