5IJA: [nife] Hydrogenase Maturation Protease Hybd From Thermococcus Kodakarensis

Citation:
Abstract
A [NiFe] hydrogenase maturation protease HybD from Thermococcus kodakarensis KOD1 (TkHybD) is involved in the cleavage of the C-terminal residues of [NiFe] hydrogenase large subunits by Ni recognition. Here, we report the crystal structure of TkHybD at 1.82 A resolution to better understand this process. TkHybD exhibits an alpha/beta/alpha sandwich fold with conserved residues responsible for the Ni recognition. Comparisons of TkHybD with homologous proteins also reveal that they share a common overall architecture, suggesting that they have similar catalytic functions. Our results including metal binding site prediction provide insight into the substrate recognition and catalysis mechanism of TkHybD. Proteins 2016; 84:1321-1327. (c) 2016 Wiley Periodicals, Inc.
PDB ID: 5IJADownload
MMDB ID: 139776
PDB Deposition Date: 2016/3/1
Updated in MMDB: 2017/10
Experimental Method:
x-ray diffraction
Resolution: 1.82  Å
Source Organism:
Similar Structures:
Biological Unit for 5IJA: monomeric; determined by author
Molecular Components in 5IJA
Label Count Molecule
Protein (1 molecule)
1
Hydrogenase-specific Maturation Endopeptidase
Molecule annotation
* Click molecule labels to explore molecular sequence information.

Citing MMDB
.