5IIS: Design, synthesis and structure activity relationship of potent pan-PIM kinase inhibitors derived from the pyridyl-amide scaffold

PDB ID: 5IISDownload
MMDB ID: 138209
PDB Deposition Date: 2016/3/1
Updated in MMDB: 2024/12
Experimental Method:
x-ray diffraction
Resolution: 2.1  Å
Source Organism:
Similar Structures:
Biological Unit for 5IIS: monomeric; determined by author and by software (PISA)
Molecular Components in 5IIS
Label Count Molecule
Protein (1 molecule)
1
Serine/threonine-protein Kinase Pim-1
(Gene symbol: PIM1)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
2
1
3-amino-N-(2'-amino-6'-methyl[4,4'-bipyridin]-3-yl)-6-(2-fluorophenyl)pyridine-2-carboxamide3-amino-N-(2'-amino-6'-methyl[4,4'-bipyridin]-3-yl)-6-(2-fluorophenyl)pyridine-2-carboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303