5I95: Crystal Structure of Human Mitochondrial Isocitrate Dehydrogenase R140Q Mutant Homodimer bound to NADPH and alpha-Ketoglutaric acid

PDB ID: 5I95Download
MMDB ID: 147682
PDB Deposition Date: 2016/2/19
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 1.54  Å
Source Organism:
Similar Structures:
Biological Unit for 5I95: dimeric; determined by software (PISA)
Molecular Components in 5I95
Label Count Molecule
Proteins (2 molecules)
2
Isocitrate Dehydrogenase [nadp], Mitochondrial
(Gene symbol: IDH2)
Molecule annotation
Chemicals and Non-standard biopolymers (16 molecules)
1
2
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATENADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
2
2
CALCIUM IONCALCIUM ION
3
8
GLYCEROLGLYCEROL
4
2
ACETATE IONACETATE ION
5
2
2-OXOGLUTARIC ACID2-OXOGLUTARIC ACID
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303