5I89: Crystal structure of the bromodomain of human CREBBP bound to the benzodiazepinone G02857790

PDB ID: 5I89Download
MMDB ID: 139821
PDB Deposition Date: 2016/2/18
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 1.07  Å
Source Organism:
Similar Structures:
Biological Unit for 5I89: monomeric; determined by author and by software (PISA)
Molecular Components in 5I89
Label Count Molecule
Protein (1 molecule)
1
Creb-binding Protein
(Gene symbol: CREBBP)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
1
ACETATE IONACETATE ION
2
1
CALCIUM IONCALCIUM ION
3
1
(4R)-6-(3-cyclopropyl-1-methyl-1H-indazol-5-yl)-4-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one(4R)-6-(3-cyclopropyl-1-methyl-1H-indazol-5-yl)-4-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303