5I59: Glutamate- and glycine-bound GluN1/GluN2A agonist binding domains with MPX 007

PDB ID: 5I59Download
MMDB ID: 143281
PDB Deposition Date: 2016/2/14
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 2.25  Å
Source Organism:
Similar Structures:
Biological Unit for 5I59: dimeric; determined by author and by software (PISA)
Molecular Components in 5I59
Label Count Molecule
Proteins (2 molecules)
1
Glutamate Receptor Ionotropic, Nmda 1,glutamate Receptor Ionotropic, Nmda 1
(Gene symbol: Grin1)
Molecule annotation
1
Glutamate Receptor Ionotropic, Nmda 2a,glutamate Receptor Ionotropic, Nmda 2A
(Gene symbol: Grin2a)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
1
GLYCINEGLYCINE
2
1
GLUTAMIC ACIDGLUTAMIC ACID
3
1
5-({[(3,4-difluorophenyl)sulfonyl]amino}methyl)-6-methyl-N-[(2-methyl-4H-1lambda~4~,3-thiazol-5-yl)methyl]pyrazine-2-carboxamide5-({[(3,4-difluorophenyl)sulfonyl]amino}methyl)-6-methyl-N-[(2-methyl-4H-1lambda~4~,3-thiazol-5-yl)methyl]pyrazine-2-carboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303