5I4V: Discovery of novel, orally efficacious Liver X Receptor (LXR) beta agonists

PDB ID: 5I4VDownload
MMDB ID: 140539
PDB Deposition Date: 2016/2/12
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 2.61  Å
Source Organism:
Similar Structures:
Biological Unit for 5I4V: dimeric; determined by author and by software (PISA)
Molecular Components in 5I4V
Label Count Molecule
Proteins (2 molecules)
1
Oxysterols Receptor Lxr-beta,nuclear Receptor Coactivator 2
(Gene symbol: NR1H2)
Molecule annotation
1
Retinoic Acid Receptor Rxr-beta,nuclear Receptor Coactivator 2
(Gene symbol: RXRB)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
{2-[(2R)-4-[4-(hydroxymethyl)-3-(methylsulfonyl)phenyl]-2-(propan-2-yl)piperazin-1-yl]-4-(trifluoromethyl)pyrimidin-5-yl}methanol{2-[(2R)-4-[4-(hydroxymethyl)-3-(methylsulfonyl)phenyl]-2-(propan-2-yl)piperazin-1-yl]-4-(trifluoromethyl)pyrimidin-5-yl}methanol
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303