5I0L: Crystal structure of the catalytic domain of MMP-12 in complex with a selective sugar-conjugated arylsulfonamide carboxylate water-soluble inhibitor (DC27)

PDB ID: 5I0LDownload
MMDB ID: 141011
PDB Deposition Date: 2016/2/4
Updated in MMDB: 2016/11
Experimental Method:
x-ray diffraction
Resolution: 2.45  Å
Source Organism:
Similar Structures:
Biological Unit for 5I0L: monomeric; determined by author
Molecular Components in 5I0L
Label Count Molecule
Protein (1 molecule)
1
Macrophage Metalloelastase
(Gene symbol: MMP12)
Molecule annotation
Chemicals and Non-standard biopolymers (10 molecules)
1
2
(2R)-2-[{(E)-2-[({(2R,3R,4R,5S,6R)-3-(acetylamino)-4,5-bis(acetyloxy)-6-[(acetyloxy)methyl]tetrahydro-2H-pyran-2-yl}carbamothioyl)amino]ethenyl}(biphenyl-4-ylsulfonyl)amino]-3-methylbutanoic acid(2R)-2-[{(E)-2-[({(2R,3R,4R,5S,6R)-3-(acetylamino)-4,5-bis(acetyloxy)-6-[(acetyloxy)methyl]tetrahydro-2H-pyran-2-yl}carbamothioyl)amino]ethenyl}(biphenyl-4-ylsulfonyl)amino]-3-methylbutanoic acid
2
2
ZINC IONZINC ION
3
3
CALCIUM IONCALCIUM ION
4
1
S-1,2-PROPANEDIOLS-1,2-PROPANEDIOL
5
1
1,2-ETHANEDIOL1,2-ETHANEDIOL
6
1
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303