5HZE: Mek1 adopts DFG-out conformation when bound to an analog of E6201

PDB ID: 5HZEDownload
MMDB ID: 150391
PDB Deposition Date: 2016/2/2
Updated in MMDB: 2024/11
Experimental Method:
x-ray diffraction
Resolution: 2.4  Å
Source Organism:
Similar Structures:
Biological Unit for 5HZE: monomeric; determined by author
Molecular Components in 5HZE
Label Count Molecule
Protein (1 molecule)
1
Dual Specificity Mitogen-activated Protein Kinase Kinase 1
(Gene symbol: MAP2K1)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
1
(3S,4R,8S,9S,11E)-8,9,16-trihydroxy-3,4-dimethyl-14-(methylamino)-3,4,5,6,9,10-hexahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione(3S,4R,8S,9S,11E)-8,9,16-trihydroxy-3,4-dimethyl-14-(methylamino)-3,4,5,6,9,10-hexahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione
2
2
MAGNESIUM IONMAGNESIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303