5HZ9: Human Fabp3 In Complex With 6-chloro-2-methyl-4-phenyl-quinoline-3- Carboxylic Acid

Citation:
Abstract
Dual inhibition of fatty acid binding proteins 4 and 5 (FABP4 and FABP5) is expected to provide beneficial effects on a number of metabolic parameters such as insulin sensitivity and blood glucose levels and should protect against atherosclerosis. Starting from a FABP4 selective focused screening hit, biostructure information was used to modulate the selectivity profile in the desired way and to design potent dual FABP4/5 inhibitors with good selectivity against FABP3. With very good pharmacokinetic properties and no major safety alerts, compound 12 was identified as a suitable tool compound for further in vivo investigations.
PDB ID: 5HZ9Download
MMDB ID: 145607
PDB Deposition Date: 2016/2/2
Updated in MMDB: 2016/12
Experimental Method:
x-ray diffraction
Resolution: 2.3  Å
Source Organism:
Similar Structures:
Biological Unit for 5HZ9: monomeric; determined by author
Molecular Components in 5HZ9
Label Count Molecule
Protein (1 molecule)
1
Fatty Acid-binding Protein, Heart(Gene symbol: FABP3)
Molecule annotation
Chemicals (9 molecules)
1
6
2
3
* Click molecule labels to explore molecular sequence information.

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