5HTC: Crystal structure of haspin (GSG2) in complex with bisubstrate inhibitor ARC-3372

PDB ID: 5HTCDownload
MMDB ID: 242515
PDB Deposition Date: 2016/1/26
Updated in MMDB: 2025/05
Experimental Method:
x-ray diffraction
Resolution: 1.5  Å
Source Organism:
synthetic construct▼
Similar Structures:
Biological Unit for 5HTC: dimeric; determined by software (PISA)
Molecular Components in 5HTC
Label Count Molecule
Proteins (2 molecules)
1
Serine/threonine-protein Kinase Haspin
Molecule annotation
1
Arc-3372 Inhibitor
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
2
(4S)-2-METHYL-2,4-PENTANEDIOL(4S)-2-METHYL-2,4-PENTANEDIOL
2
1
SODIUM IONSODIUM ION
3
1
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
4
1
(2R)-2-{[6-({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]carbonyl}amino)hexanoyl]amino}butanedioic acid (non-preferred name)(2R)-2-{[6-({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]carbonyl}amino)hexanoyl]amino}butanedioic acid (non-preferred name)
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303