5HTB: Crystal structure of haspin (GSG2) in complex with bisubstrate inhibitor ARC-3353

PDB ID: 5HTBDownload
MMDB ID: 229639
PDB Deposition Date: 2016/1/26
Updated in MMDB: 2023/05
Experimental Method:
x-ray diffraction
Resolution: 1.7  Å
Source Organism:
synthetic construct▼
Similar Structures:
Biological Unit for 5HTB: dimeric; determined by author and by software (PISA)
Molecular Components in 5HTB
Label Count Molecule
Proteins (2 molecules)
1
Serine/threonine-protein Kinase Haspin
Molecule annotation
1
Arc-3353 Inhibitor
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
1
(4R)-2-METHYLPENTANE-2,4-DIOL(4R)-2-METHYLPENTANE-2,4-DIOL
2
1
SODIUM IONSODIUM ION
3
1
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
4
1
(3R)-4-amino-3-{[6-({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]carbonyl}amino)hexanoyl]amino}-4-oxobutanoic acid (non-preferred name)(3R)-4-amino-3-{[6-({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]carbonyl}amino)hexanoyl]amino}-4-oxobutanoic acid (non-preferred name)
5
1
(4S)-2-METHYL-2,4-PENTANEDIOL(4S)-2-METHYL-2,4-PENTANEDIOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303