5HRO: STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE In COMPLEX WITH A DNA aptamer and an Alpha-carboxy nucleoside phosphonate inhibitor (alpha-CNP)

PDB ID: 5HRODownload
MMDB ID: 139759
PDB Deposition Date: 2016/1/23
Updated in MMDB: 2024/12
Experimental Method:
x-ray diffraction
Resolution: 2.75  Å
Source Organism:
synthetic construct▼
Similar Structures:
Biological Unit for 5HRO: trimeric; determined by author and by software (PISA)
Molecular Components in 5HRO
Label Count Molecule
Proteins (2 molecules)
1
Hiv-1 Reverse Transcriptase P66 Subunit
Molecule annotation
1
Hiv-1 Reverse Transcriptase P51 Subunit
Molecule annotation
Nucleotide(1 molecule)
1
DNA (38-mer)
Molecule annotation
Chemicals and Non-standard biopolymers (13 molecules)
1
2
alpha-D-glucopyranosealpha-D-glucopyranose
2
2
beta-D-fructofuranosebeta-D-fructofuranose
3
3
MAGNESIUM IONMAGNESIUM ION
4
1
[(1R)-2-methoxy-1-{[(1S,3R)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)cyclopentyl]oxy}-2-oxoethyl]phosphonic acid[(1R)-2-methoxy-1-{[(1S,3R)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)cyclopentyl]oxy}-2-oxoethyl]phosphonic acid
5
5
SULFATE IONSULFATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303