5HI3: Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists

PDB ID: 5HI3Download
MMDB ID: 142588
PDB Deposition Date: 2016/1/11
Updated in MMDB: 2017/12
Experimental Method:
x-ray diffraction
Resolution: 2.15  Å
Source Organism:
synthetic construct▼
Similar Structures:
Biological Unit for 5HI3: heptameric; determined by author
Molecular Components in 5HI3
Label Count Molecule
Proteins (7 molecules)
2
Interleukin-17a
Molecule annotation
2
Cat-2000 FAB Heavy Chain
Molecule annotation
2
Cat-2000 FAB Light Chain
Molecule annotation
1
Synthetic Il-17a Peptide Inhibitor
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
N-(4-{2-[({1-[2-(dimethylamino)-2-oxoethyl]cyclopentyl}acetyl)amino]ethyl}phenyl)-2-fluoro-Nalpha-[(1-methyl-1H-pyrazol-5-yl)carbonyl]-L-phenylalaninamideN-(4-{2-[({1-[2-(dimethylamino)-2-oxoethyl]cyclopentyl}acetyl)amino]ethyl}phenyl)-2-fluoro-Nalpha-[(1-methyl-1H-pyrazol-5-yl)carbonyl]-L-phenylalaninamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303