5HI2: BRAF Kinase domain b3aC loop deletion mutant in complex with sorafenib

PDB ID: 5HI2Download
MMDB ID: 138175
PDB Deposition Date: 2016/1/11
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 2.512  Å
Source Organism:
Similar Structures:
Biological Unit for 5HI2: monomeric; determined by author and by software (PISA)
Molecular Components in 5HI2
Label Count Molecule
Protein (1 molecule)
1
Serine/threonine-protein Kinase B-raf
(Gene symbol: BRAF)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303