5HA9: Crystal structure-based design and disovery of a novel PARP1 antiagonist (BL-PA10) that induces apoptosis and inhibits metastasis in triple negative breast cancer

PDB ID: 5HA9Download
MMDB ID: 137327
PDB Deposition Date: 2015/12/30
Updated in MMDB: 2018/07
Experimental Method:
x-ray diffraction
Resolution: 4.01  Å
Source Organism:
Similar Structures:
Biological Unit for 5HA9: dimeric; determined by author and by software (PISA)
Molecular Components in 5HA9
Label Count Molecule
Proteins (2 molecules)
2
Poly [adp-ribose] Polymerase 1
(Gene symbol: PARP1)
Molecule annotation
Chemicals and Non-standard biopolymers (9 molecules)
1
2
GLYCEROLGLYCEROL
2
6
SULFATE IONSULFATE ION
3
1
AmitriptylineAmitriptyline
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303