5GTZ: Crystal structure of EGFR 696-1022 T790M in complex with JTS-1-39

PDB ID: 5GTZDownload
MMDB ID: 154211
PDB Deposition Date: 2016/8/24
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 2.999  Å
Source Organism:
Similar Structures:
Biological Unit for 5GTZ: monomeric; determined by author
Molecular Components in 5GTZ
Label Count Molecule
Protein (1 molecule)
1
Epidermal Growth Factor Receptor
(Gene symbol: EGFR)
Molecule annotation
Chemicals and Non-standard biopolymers (10 molecules)
1
1
N-[5-[[5-chloranyl-4-[(2-propan-2-ylsulfonylphenyl)amino]pyrimidin-2-yl]amino]-2-(4-ethylpiperazin-1-yl)-4-methoxy-phenyl]prop-2-enamideN-[5-[[5-chloranyl-4-[(2-propan-2-ylsulfonylphenyl)amino]pyrimidin-2-yl]amino]-2-(4-ethylpiperazin-1-yl)-4-methoxy-phenyl]prop-2-enamide
2
4
1,2-ETHANEDIOL1,2-ETHANEDIOL
3
5
CHLORIDE IONCHLORIDE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303