5G5W: Structure guided design and discovery of Indazole ethers as highly potent, non-steroidal Glucocorticoid receptor modulators

PDB ID: 5G5WDownload
MMDB ID: 147249
PDB Deposition Date: 2016/6/8
Updated in MMDB: 2019/04
Experimental Method:
x-ray diffraction
Resolution: 2.2  Å
Source Organism:
Similar Structures:
Biological Unit for 5G5W: dimeric; determined by author and by software (PISA)
Molecular Components in 5G5W
Label Count Molecule
Proteins (2 molecules)
1
Glucocorticoid Receptor
(Gene symbol: NR3C1)
Molecule annotation
1
Nuclear Receptor Coactivator 2
(Gene symbol: NCOA2)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
1,2-ETHANEDIOL1,2-ETHANEDIOL
2
1
2,2,2-trifluoro-N-[(1R,2S)-1-{[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy}-1-phenylpropan-2-yl]acetamide2,2,2-trifluoro-N-[(1R,2S)-1-{[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy}-1-phenylpropan-2-yl]acetamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303