5FMG: Structure and function based design of Plasmodium-selective proteasome inhibitors

PDB ID: 5FMGDownload
MMDB ID: 154020
PDB Deposition Date: 2015/11/4
Updated in MMDB: 2022/11
Experimental Method:
electron microscopy
Resolution: 3.6  Å
Source Organism:
Similar Structures:
Biological Unit for 5FMG: 28-meric; determined by software (PISA)
Molecular Components in 5FMG
Label Count Molecule
Proteins (28 molecules)
2
Proteasome Subunit Alpha, Putative
Molecule annotation
2
Proteasome Subunit Alpha Type 2, Putative
Molecule annotation
2
Proteasome Subunit Alpha Type
Molecule annotation
2
Proteasome Subunit Alpha Type
Molecule annotation
2
Proteasome Subunit Alpha Type
Molecule annotation
2
Proteosome Subunit Alpha Type 1, Putative
Molecule annotation
2
Proteasome Component C8, Putative
Molecule annotation
2
Proteasome, Putative
Molecule annotation
2
Proteasome Subunit Beta Type
Molecule annotation
2
Beta3 Proteasome Subunit, Putative
Molecule annotation
2
Proteasome Subunit Beta Type
Molecule annotation
2
Proteasome Subunit Beta Type
Molecule annotation
2
Proteasome Subunit Beta Type
Molecule annotation
2
Proteasome Subunit Beta Type
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
2
(2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide (Link to PubChem not yet available)(2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303