5FGK: CDK8-CYCC IN COMPLEX WITH 8-[3-(3-Amino-1H-indazol-6-yl)-5-chloro- pyridine-4-yl]-2,8-diaza-spiro[4.5]decan-1-one

PDB ID: 5FGKDownload
MMDB ID: 136282
PDB Deposition Date: 2015/12/20
Updated in MMDB: 2024/05
Experimental Method:
x-ray diffraction
Resolution: 2.36  Å
Source Organism:
Similar Structures:
Biological Unit for 5FGK: dimeric; determined by software (PISA)
Molecular Components in 5FGK
Label Count Molecule
Proteins (2 molecules)
1
Cyclin-dependent Kinase 8
(Gene symbol: CDK8)
Molecule annotation
1
Cyclin-c
(Gene symbol: CCNC)
Molecule annotation
Chemicals and Non-standard biopolymers (11 molecules)
1
1
8-[3-(3-azanyl-2~{H}-indazol-6-yl)-5-chloranyl-pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one8-[3-(3-azanyl-2~{H}-indazol-6-yl)-5-chloranyl-pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one
2
1
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
3
2
1,2-ETHANEDIOL1,2-ETHANEDIOL
4
7
FORMIC ACIDFORMIC ACID
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303