5FGF: Yeast 20S proteasome beta5-H(-2)A-T1A-K81R triple mutant in complex with Carfilzomib

PDB ID: 5FGFDownload
MMDB ID: 137728
PDB Deposition Date: 2015/12/20
Updated in MMDB: 2016/12
Experimental Method:
x-ray diffraction
Resolution: 2.6  Å
Source Organism:
Similar Structures:
Biological Unit for 5FGF: 28-meric; determined by author
Molecular Components in 5FGF
Label Count Molecule
Proteins (28 molecules)
2
Proteasome Subunit Alpha Type-2
(Gene symbol: PRE8)
Molecule annotation
2
Proteasome Subunit Alpha Type-3
(Gene symbol: PRE9)
Molecule annotation
2
Proteasome Subunit Alpha Type-4
(Gene symbol: PRE6)
Molecule annotation
2
Proteasome Subunit Alpha Type-5
(Gene symbol: PUP2)
Molecule annotation
2
Proteasome Subunit Alpha Type-6
(Gene symbol: PRE5)
Molecule annotation
2
Probable Proteasome Subunit Alpha Type-7
(Gene symbol: PRE10)
Molecule annotation
2
Proteasome Subunit Alpha Type-1
(Gene symbol: SCL1)
Molecule annotation
2
Proteasome Subunit Beta Type-2
(Gene symbol: PUP1)
Molecule annotation
2
Proteasome Subunit Beta Type-3
(Gene symbol: PUP3)
Molecule annotation
2
Proteasome Subunit Beta Type-4
(Gene symbol: PRE1)
Molecule annotation
2
Proteasome Subunit Beta Type-5
(Gene symbol: PRE2)
Molecule annotation
2
Proteasome Subunit Beta Type-6
(Gene symbol: PRE7)
Molecule annotation
2
Proteasome Subunit Beta Type-7
(Gene symbol: PRE4)
Molecule annotation
2
Proteasome Subunit Beta Type-1
(Gene symbol: PRE3)
Molecule annotation
Chemicals and Non-standard biopolymers (19 molecules)
1
9
MAGNESIUM IONMAGNESIUM ION
2
4
CHLORIDE IONCHLORIDE ION
3
4
N-{(2S)-2-[(morpholin-4-ylacetyl)amino]-4-phenylbutanoyl}-L-leucyl-N-[(2R,3S,4S)-1,3-dihydroxy-2,6-dimethylheptan-4-yl]-L-phenylalaninamideN-{(2S)-2-[(morpholin-4-ylacetyl)amino]-4-phenylbutanoyl}-L-leucyl-N-[(2R,3S,4S)-1,3-dihydroxy-2,6-dimethylheptan-4-yl]-L-phenylalaninamide
4
2
2-(N-MORPHOLINO)-ETHANESULFONIC ACID2-(N-MORPHOLINO)-ETHANESULFONIC ACID
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303