5FFM: Yellow Fever Virus Helicase

Yellow fever virus (YFV), a member of the Flavivirus genus, has a plus-sense RNA genome encoding a single polyprotein. Viral protein NS3 includes a protease and a helicase that are essential to virus replication and to RNA capping. The 1.8-A crystal structure of the helicase region of the YFV NS3 protein includes residues 187 to 623. Two familiar helicase domains bind nucleotide in a triphosphate pocket without base recognition, providing a site for nonspecific hydrolysis of nucleoside triphosphates and RNA triphosphate. The third, C-terminal domain has a unique structure and is proposed to function in RNA and protein recognition. The organization of the three domains indicates that cleavage of the viral polyprotein NS3-NS4A junction occurs in trans.
PDB ID: 5FFMDownload
MMDB ID: 135240
PDB Deposition Date: 2015/12/18
Updated in MMDB: 2015/12
Experimental Method:
x-ray diffraction
Resolution: 2.6  Å
Source Organism:
Similar Structures:
Biological Unit for 5FFM: monomeric; determined by author
Molecular Components in 5FFM
Label Count Molecule
Protein (1 molecule)
Serine Protease NS3(Gene symbol: YFVgp1)
Molecule annotation
* Click molecule labels to explore molecular sequence information.

Citing MMDB